Tag: hydroxychloroquine

  • Price of hydroxychloroquine skyrockets in Nigeria

    The price of the anti-malaria drug hydroxychloroquine has skyrocketed in Nigeria, according to the government’s consumer protection body.

    There’s been widespread interest in hydroxychloroquine as both a preventative measure and for treating patients with coronavirus but the World Health Organization (WHO) says the drug doesn’t reduce death rates in patients with coronavirus.

    Despite the lack of evidence, the Federal Competition and Consumer Protection Commission’s audit of prices across the country has observed an astonishing rise in the drug’s price in the last four months.

    It found that – a packet of 60 tablets selling for 3,000 naira ($8; £6) four months ago – could be on sale in pharmacies for as much as 75,000 naira ($194; £147) now.

    In a letter published on their Twitter account the body described “excessive and unconscionable pricing”.

    It added that “unreasonable, unjust and irrational prices or margins are a criminal offence” in Nigeria.

    Promotion by leading political figures such as US President Donald Trump has led to both hydroxychloroquine, and the related drug chloroquine, becoming the subject of widespread speculation online about their potential benefits and harmful effects.

    This has led to high demand for the drugs and global supply shortages.

    But despite some early studies raising hopes, one subsequent larger scale trial has shown it’s not effective as a treatment and the WHO has halted its trials.

    Source: bbc.com

  • Coronavirus: Nigerian drug stores hike hydroxychloroquine price

    Hydroxychloroquine, the controversial drug used in the treatment of COVID-19, is being sold in one drug store in Rivers State, South-South Nigeria, at an outrageous price of N50,000.

    Hydroxychloroquine, before now, was essentially used for malaria treatment. It was never known to be this costly, as at then.

    The drug began selling at about N3,000 around March in Nigeria during the outbreak of the novel Coronavirus in the country, a pharmacist told PREMIUM TIMES.

    Some person who apparently wanted to alert Nigerians on the exorbitant price of the COVID-19 drug took a photo of its pack, with the price tag, name and the telephone contact of the drug store on it, and then got it circulated on WhatsApp over the weekend.

    The drug, as shown in the photo, is Zentiva brand, with 60 tablets (200mg) in a pack. The store selling it is Ebus Pharmacy Ltd, at Eastern bypass, Port Harcourt, Rivers State.

    The N50,000 price tag attracted outrage from Nigerians who felt it was too high.

    Ebus Pharmacy said the retail price of the hydroxychloroquine was dependent on how much money they used in importing it.

    “What is your concern about how much I sell what I buy when you don’t know how much I bought it?” A man from Ebus Pharmacy told PREMIUM TIMES, Monday, on telephone.

    The man refused to disclose his name and position in the drug store. But Truecaller, a phone app, identified him as Boniface Ebugosi.

    “Have you checked around here in Port Harcourt, Lagos or Abuja to know the price (of the hydroxychloroquine) before you say it’s outrageous? Or is it only hydroxychloroquine that you know the price has changed since COVID-19 came to be?” Mr Ebugosi said, while arguing that the naira was depreciating against the dollar and that it was negatively affecting imports.

    He said people were free to buy at other drug stores if they felt Ebus Pharmacy was selling their products at exorbitant prices.

    PREMIUM TIMES asked Mr Ebugosi how much his store was selling hydroxychloroquine before now.

    “Those things do not hold water,” he responded. “What we are saying now is: do you have it? How much is the price? Bring it.”

    Mr Ebugosi said besides hydroxychloroquine, the prices of other drugs used in COVID-19 treatment, like vitamin C and zinc, have increased in Nigeria.

    He said prices of food items too have increased in the country.

    Really, the prices of vitamin C and zinc has increased across Nigeria because of COVID-19.

    In Uyo, Akwa Ibom State, for instance, most drug stores as of last week were selling at about N5,000, 100 tablets of 100mg zinc in a small container. On Monday, the price suddenly increased to N5,500 in some of the stores in the city.

    “At some point it was selling at N8,000,” a pharmacist in Uyo told PREMIUM TIMES, Monday evening.

    “Before COVID-19 it was N2,000,” he added.

    “It is not anybody’s making. Ebus, as a company which has a name to protect, would want to sell at the cheapest prices so that our customers would remain with us,” Mr Ebugosi said of the exorbitant price of hydroxychloroquine at his store.

    PREMIUM TIMES’ checks at three other drug stores in Port Harcourt showed that they were also selling hydroxychloroquine at about the same amount with Ebus Pharmacy.

    One of the stores said they were selling it at N54,000, but had ran out of stock.

    Some other stores in the city were selling between N15,000 and N18,000, another brand of hydroxychloroquine which contains 20 tablets in a pack, unlike the brand at Ebus Pharmacy which has 60 tablets.

    A federal agency in Nigeria, the Federal Competition & Consumer Protection Commission (FCCPC) intervened in a similar case in Lagos in March and forced a drug store – Medmark Pharmacy – to make a refund to a woman who bought a 500ml hand sanitiser at an exorbitant price of N19,950.

    The incident happened at the time many Nigerians were involved in panic-buying of hand sanitiser and face mask because of the Coronavirus.

    The woman who felt she was being ripped off said she thought the price of the sanitiser was N1,950.

    The head of FCCPC, Babatunde Irukera, told PREMIUM TIMES, Monday evening, that his agency was investigating the sales of hydroxychloroquine at exorbitant price in Port Harcourt.

    Ebus Pharmacy was not open on Sunday when operatives from the FCCPC visited it, Mr Irukera said.

    The operatives went back to the drug store on Monday, according to Mr Irukera, but hydroxychloroquine was not on the shelf.

    The manager of Ebus Pharmacy was said to have declined to give information to operatives on the sales of hydroxychloroquine in the store.

    “Our people will be there tomorrow (Tuesday) to check the inventory in the pharmacy,” Mr Irukera said.

    Mr Irukera said his agency has also received information about a location where hydroxychloroquine was being sold at N75,000 in Victoria Island, Lagos.

    He said the agency was conducting surveillance operations on the Lagos location and other locations in Abuja.

    A pharmacist in Port Harcourt who did not want his name mentioned in the report attributed the exorbitant price of hydroxychloroquine to a viral video of a U.S-based medical doctor, Stella Immanuel who claimed she has used the drug to successfully treat more than 300 COVID-19 patients in America.

    “Nobody needs to get sick. This virus has a cure – it is called hydroxychloroquine. I have treated over 350 patients and not had one death,” Ms Immanuel said in the video, surrounded by other doctors with similar views.

    The video, which many people believed was done to promote the U.S President Donald Trump’s political ambition, prompted a global discourse especially among medical experts on hydroxychloroquine, but it was quickly taken down by Facebook and Twitter on grounds that it was promoting unproven medical claims.

    Mr Trump has been advocating for the use of the anti-malaria drug in the treatment of COVID-19, contrary to the advice of the World Health Organisation and the U.S Food And Drug Administration.

    Coronavirus has been on the increase in Nigeria. The number of confirmed cases in the country is 43,841 as of August 2.

    Eight hundred and eighty-eight people have died so far from the virus, according to the data from the Nigeria Centre for Disease Control, while 20,308 have been treated and discharged from hospital.

    Lagos, Nigeria’s commercial capital, remains the epicentre of the virus, with 15,267 confirmed cases, followed by Abuja, with 3,972.

    Rivers, an oil-producing state with over 5 million population, has 1,829 cases, the fifth highest in the country.

    Some states in Nigeria, overwhelmed by the number of cases, have resorted to home-treatment for many COVID-19 patients, and in some cases the patients are asked to procure the drugs for their treatment.

    The implication here is that if drug stores arbitrarily fix high prices for COVID-19 drugs, some poor Nigerians face the risk of being excluded from treatment for COVID-19 and may die without getting medical help.

    Source: allafrica.com

  • Coronavirus: Trump sticks by revoked hydroxychloroquine

    US President Donald Trump has again defended the use of hydroxychloroquine to ward off coronavirus, contradicting his own public health officials.

    He argued the malaria medication was only rejected as a Covid-19 treatment because he had suggested it.

    His remarks come after Twitter banned his eldest son for posting a clip touting hydroxychloroquine.

    There is no evidence the drug can fight the virus, and regulators warn it may cause heart problems.

    Last month, the US Food and Drug Administration (FDA) cautioned against the use of the drug for treatment of the coronavirus, following reports of “serious heart rhythm problems” and other health issues.

    The FDA also revoked its emergency-use authorisation for the drug to treat Covid-19. The World Health Organization (WHO) says “there is currently no proof” that it is effective as a treatment or prevents Covid-19.

    Studies commissioned by the WHO, the US National Institutes of Health and other medical researchers around the world have found no evidence that hydroxychloroquine – when used with or without the antibiotic azithromycin, as repeatedly recommended by President Trump – helps treat coronavirus.

    Hydroxychloroquine was first touted in March by Mr Trump, 74, in relation to Covid-19. Two months later he surprised journalists by saying he had begun taking the unproven medication to ward off the virus.

    On Tuesday, the president told reporters at the White House: “I can only say that from my standpoint, and based on a lot of reading and a lot of knowledge about it, I think it could have a very positive impact in the early stages.

    “I don’t think you lose anything by doing it, other than politically it doesn’t seem too popular.”

    He added: “When I recommend something, they like to say ‘don’t use it.’”

    President Trump and his son Donald Trump Jr were among social media users who shared video late on Monday of a group called America’s Frontline Doctors advocating hydroxychloroquine as a Covid-19 treatment.

    Facebook and Twitter removed the content, flagging it as misinformation, but not before more than 17 million people had seen one of the clips.

    Twitter also banned the US president’s eldest son from tweeting for 12 hours as a penalty for sharing the clip.

    The video in question showed doctors speaking outside the US Supreme Court at an event organised by Tea Party Patriots Action, a group that is not required to disclose its donors and has helped fund a pro-Trump political action committee.

    In the video, Dr Stella Immanuel, a physician from Houston, says she has successfully treated 350 coronavirus patients “and counting” with hydroxychloroquine.

    The president said on Tuesday: “I think they’re very respected doctors. There was a woman who was spectacular in her statements about it.”

    According to the Daily Beast, Dr Immanuel has previously claimed the government is run by “reptilians” and that scientists are developing a vaccine to stop people being religious, among other bizarre views.

    America’s Frontline Doctors’ founder Simone Gold accused social media companies of censorship for removing the hydroxychloroquine video.

    “Treatment options for COVID-19 should be debated, and spoken about among our colleagues in the medical field,” she tweeted. “They should never, however, be censored and silenced.”

    Late on Monday, Mr Trump also retweeted several tweets critical of Dr Anthony Fauci, a leading member of the White House coronavirus task force.

    But in Tuesday’s briefing the president denied he was criticising the director of the National Institute of Allergy and Infectious Diseases, insisting: “I get along with him very well.”

    Asked about hydroxychloroquine earlier on Tuesday, Dr Fauci said the medication was not an appropriate treatment for Covid-19.

    He told ABC News’ morning show the drug was “not effective in coronavirus disease”.

    At Tuesday’s briefing, Mr Trump questioned why the White House coronavirus expert and his fellow task force member Dr Deborah Birx were popular, but his administration was not.

    He said: “They’re highly thought of but nobody likes me. It can only be my personality, that’s all.”

    The US now has more than 4.3 million reported cases of Covid-19, and more than 149,000 deaths.

    Source: BBC

  • Hydroxychloroquine trial to restart

    The UK has approved the resumption of tests into whether a controversial malaria drug can be used to treat coronavirus.

    Regulators say hydroxychloroquine and a similar drug, chloroquine, can be given to healthcare workers in a clinical study to test the theory.

    Recruitment to the COPCOV trial was paused earlier this year due to concerns about the drug’s side-effects. An influential article had found it increases the risk of death in coronavirus patients, but the article has since been retracted over data concerns.

    Although other studies suggest hydroxychloroquine is not a life-saver for people who are already ill with coronavirus, researchers are keen to continue exploring whether it might prevent infections.

    The COPCOV trial will see chloroquine, hydroxychloroquine or a placebo given to more than 40,000 healthcare workers from Europe, Africa, Asia and South America.

    Source: bbc.com

  • COVID 19: Tobinco produces hydroxychloroquine locally

    Entrance Pharmaceuticals and Research Centre, the manufacturing subsidiary of Tobinco Group of companies has locally produced hydroxychloroquine, a drug for managing coronavirus cases.

    This is in fulfillment of a promise made by the Chairman of the Group, Nana Amo Tobbin I to produce the drug locally to help manage covid-19 cases in Ghana.

    The Group has therefore presented 1,000 courses of Hydroxychloroquine worth over GH¢ 100,000 and 18,000 bottles of Foligrow to the Ministry of Health to support the government in the fight against COVID-19 in Ghana.

    Hydroxychloroquine has been endorsed by WHO for the treatment of COVID-19 patients.

    Receiving the donation, the Deputy Minister of Health, Dr Bernard Okoe Boye commended Nana Amo Tobbin I and the Entrance Pharmaceuticals and Research Centre for the gesture.

    He noted that for the government to succeed in the fight against COVID-19, it would need the partnership of the private sectors, such as the Tobinco Group, expressing the hope that the partnership would last.

    It would be recalled that the EXIMBANK Ghana, about a month ago, made a commitment to advance a credit facility to Entrance Pharmaceuticals and Research Centre to produce hydroxychloroquine and azithromycin locally for the management of COVID-19 cases.

    Mr Kwadwo Asare Twerefour, MD for Entrance Pharmaceuticals and Research Centre, presenting the drugs to Dr Okoe Boye, Deputy Health Minister

    Dr Okoe Boye, gave an assurance that the Ministry would ensure that the process of securing funding from EXIMBANK to commence the production of the drugs on a large scale was expedited.

    In an interview with journalists after the presentation, Nana Amo Tobbin 1 reiterated that before the partnership, the company had decided to produce hydroxychloroquine and other drugs to support the government in the fight against covid-19.

    He also made it known that due to the scarcity of the drug, some African countries had already contacted the company to produce the drug for them.

    However, he stated that the company was looking up to the funding as promised by the government to enable the company produce more for local consumption, before it could supply the other countries with the drug.
    Nana Amo Tobbin 1 cautioned that the hydroxychloroquine should only be taken under a doctor’s prescription and not for counter sales.

    Mr Kwadwo Asare Twerefour, MD for Entrance Pharmaceuticals and Research Centre, thanked the Food and Drugs Authority (FDA) for ensuring the drugs went through all the needed processes in due time.

    He said the company is still researching and would produce the rest of the drugs that were needed to fight the disease.

    He expressed the hope that the money promised by EXIM Bank would materialise in due time so that the company could produce more of the drugs to supply the local and the international markets.

    Source: graphic.com.gh

  • Hydroxychloroquine is no longer authorized to treat coronavirus in France

    The French government on Wednesday repealed the regulations authorizing the prescription of hydroxychloroquine against Covid-19 in hospitals in France, following an unfavorable opinion from the High council for public health, according to a decree in the Official Journal, reports the Sputnik news agency, citing AFP.

    Since the end of March, hydroxychloroquine – a drug derived from the anti-malarial drug chloroquine – could be prescribed as an exception to the hospital and only for severely ill patients, on the collective decision of the doctors.

    WHO director-general Tedros Adhanom Ghebreyesus announced Monday that tests for hydroxychloroquine and chloroquine in the fight against Covid-19 have been temporarily suspended by the organization.

    He noted that these drugs were still considered to be safe for patients with autoimmune diseases and malaria.

    According to Sputnik, the Medicines Agency also said Tuesday, “wishing to suspend” clinical trials with this molecule in France, following the decision of the WHO. The High Council of Public Health has also recommended limiting its use.

    For his part, Didier Raoult, who defends the use of hydroxychloroquine in the treatment of the disease, condemned recent studies, skeptical about its effectiveness, declaring that they were based on a “big data badly controlled”.

    Source: GNA

  • Who is still using hydroxychloroquine?

    Claims that hydroxychloroquine could prove a viable treatment for Coronavirus have been dealt a new blow after France stopped doctors from using the anti-malarial drug for Covid-19 patients. But where is it still being used and who is continuing to research it?

    In the US, the Food and Drug Administration allowed “emergency use” in hospital settings, but warned against using to treat Covid-19 in other settings – apart from clinical trials – because of the risks of heart problems.

    Brazil has relaxed restrictions on the drug, allowing it to be used in mild cases as well as for those seriously ill in hospital.

    And the Indian government has expanded its use as a preventative medicine to all healthcare workers

    No clinical study has recommended the drug for coronavirus treatment and the World Health Organization this week temporarily suspended its trials over safety fears.

    But other studies are under way, including one by Swiss drugmaker Novartis in the US and a global study by the University of Oxford-backed Mahidol Oxford Tropical Medicine Research Unit in Thailand.

    Also, Nigeria has vowed to press ahead with clinical trials of the related drug chloroquine despite the WHO decision.

    Source: bbc.com

  • WHO suspends coronavirus hydroxychloroquine trial

    The World Health Organization (WHO) has temporarily suspended testing of the malaria drug hydroxychloroquine as a potential treatment for COVID-19 as a precautionary measure, WHO Director-General Tedros Adhanom Ghebreyesus said during a news conference on Monday.

    Meanwhile, Mike Ryan, head of the WHO emergencies programme, warned in the same virtual news conference that, despite countries easing lockdowns, the world is “right in the middle of the first wave” of the outbreak, and a there could be a second peak within the wave.

    The statements come days after US President Donald Trump announced he had been taking hydroxychloroquine as a preventive measure against the virus. The president, who has said he has since stopped taking the drug, had long touted its benefits as a possible treatment for COVID-19, the disease caused by the novel coronavirus, even as health experts warned it might not be safe.

    “The executive group has implemented a temporary pause of the hydroxychloroquine arm within the Solidarity trial while the safety data is reviewed by the data safety monitoring board,” Tedros said in the online briefing.

    The WHO had previously recommended against using hydroxychloroquine to treat or prevent coronavirus infections, except as part of clinical trials.

    Ryan added the decision to suspend trials of hydroxychloroquine had been taken out of “an abundance of caution”.

    Other arms of the WHO’s so-called “Solidarity Trial” – a large international initiative to hold clinical tests of potential treatments for the virus – would continue, the officials said.

    Source: aljazeera.com

  • Coronavirus: Trump says he is taking unproven drug hydroxychloroquine

    US President Donald Trump has said he is taking hydroxychloroquine to ward off Coronavirus, despite public health officials warning it may be unsafe.

    Speaking at the White House, he told reporters he started taking the malaria and lupus medication recently.

    “I’m taking it for about a week and a half now and I’m still here, I’m still here,” was his surprise announcement.

    There is no evidence hydroxychloroquine can fight coronavirus, and regulators warn the drug may cause heart problems.

    What did Trump say?

    The 73-year-old president was hosting a meeting devoted to the struggling restaurant industry on Monday, when he caught reporters unawares by revealing he was taking the drug.

    “You’d be surprised at how many people are taking it, especially the frontline workers before you catch it, the frontline workers, many, many are taking it,” he told reporters. “I happen to be taking it.”

    Asked what was his evidence of hydroxychloroquine’s positive benefits, Mr Trump said: “Here’s my evidence: I get a lot of positive calls about it.”

    He added: “I’ve heard a lot of good stories [about hydroxychloroquine] and if it’s not good, I’ll tell you right I’m not going to get hurt by it.”

    Though some people in the White House have tested positive for coronavirus, the president said again on Monday he had “zero symptoms” and was being tested frequently.

    He added that he has been taking a daily zinc supplement and received a single dose of azithromycin, an antibiotic meant to prevent infection.

    When asked whether the White House physician had recommended he start taking the disputed remedy, Mr Trump said he himself had requested it.

    Dr Sean Conley, physician to the president, said in a statement issued through the White House later on Monday that Mr Trump was in “very good health” and “symptom-free”.

    The US Navy officer added: “After numerous discussions he and I had regarding the evidence for and against the use of hydroxychloroquine, we concluded the potential benefit from treatment outweighed the relative risks.”

    What have US health officials said?

    The US Food and Drug Administration (FDA) last month issued an advisory saying that hydroxychloroquine has “not been shown to be safe and effective”.

    It cited reports that the drug can cause serious heart rhythm problems in Covid-19 patients.

    The FDA warned against use of the medication outside hospitals, where the agency has granted temporary authorisation for its use in some cases. Clinical trials of the drug are also under way.

    The Centers for Disease Control (CDC) says there are no approved drugs or therapeutics to prevent or treat Covid-19, which is confirmed to have infected more than 1.5 million people in the US, killing over 90,000 patients.

    Source: bbc.com

  • Hydroxychloroquine rated most effective coronavirus treatment, poll of doctors finds

    An international poll of thousands of doctors rated the Trump-touted anti-malaria drug hydroxychloroquine the best treatment for the novel coronavirus.

    Of the 6,227 physicians surveyed in 30 countries, 37 percent rated hydroxychloroquine the “most effective therapy” for combating the potentially deadly illness, according to the results released Thursday.

    The survey, conducted by the global health care polling company Sermo, also found that 23 percent of medical professionals had prescribed the drug in the US — far less than other countries.

    “Outside the US, hydroxychloroquine was equally used for diagnosed patients with mild to severe symptoms whereas in the US it was most commonly used for high risk diagnosed patients,” the survey found.

    The medicine was most widely used in Spain, where 72 percent of physicians said they had prescribed it.

    A debate about hydroxychloroquine was sparked two weeks ago after President Trump touted the drug as a possible “game-changer” in the fight against the COVID-19 pandemic, prompting critics to accuse him of peddling unproven, untested remedies.

    To date, “there is no evidence” that any medicine “can prevent or cure the disease,” according to the World Health Organization.

    But Sermo CEO Peter Kirk called the polling results a “treasure trove of global insights for policymakers.”

    “Physicians should have more of a voice in how we deal with this pandemic and be able to quickly share information with one another and the world,” he said in a press release.

    The 30 countries where doctors were surveyed included Europe, South America and Australia — and no incentives were provided to participate, the company said.

    Source: Natalie O’Neill | nypost.com